Mice lacking the Bmi1 gene or the Mel18 gene show a posterior transformation of the axial skeleton which correlates with an anterior shift of several Hox gene expression boundaries, similar to the Drosophila PcG loss of function mutants (Akasaka et al., 1996; van der Lugt et al., 1996). The murine M33 protein,prada outlet usawhich shares homology with the Drosophila Polycomb (Pc) protein, was shown to rescue in part the Pc mutant phenotype in transgenic flies (Muller, 1995). Furthermore, Bmi1 has been found to interact with MPc2, a murine homolog of Pc protein, and Mph1/Rae28, which shares homology with the Drosophila polyhomeoticlongchamps pas cher(ph) protein (Alkema et al., 1997b).

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